abstract：:1. The development of endogenous cholecystokinin (CCK) effects on food intake was studied in normal and undernourished growing rats of postnatal day 1-22. 2. Food intake was estimated by recording the gain in body weight before weaning. 3. l-phenylalanine, a potent stimulant of endogenous CCK release, suppressed 30 mi...

journal_title：Progress in neuro-psychopharmacology & biological psychiatry

authors： Mathur R,Manchanda SK

更新日期：1991-01-01 00:00:00

abstract：:1. Agonists may act at any one of three sites on the N-methyl-D-aspartate (NMDA) receptor-effector complex to promote opening of the associated ion channel. The three sites are activated by i) NMDA, L-glutamate, aspartate, and other dicarboxylic amino acids; ii) glycine, D-serine, D-cycloserine, and others; iii) the p...

journal_title：Progress in neuro-psychopharmacology & biological psychiatry

authors： Lehmann J,Colpaert F,Canton H

更新日期：1991-01-01 00:00:00

abstract：:1. The plasma concentrations of unconjugated phenylacetic acid and m-hydroxyphenylacetic acid are lower in male than in female subjects. 2. The plasma concentrations of unconjugated phenylacetic acid and mandelic acid decrease with increasing weight and height for all subjects combined. The same relationships apply fo...

journal_title：Progress in neuro-psychopharmacology & biological psychiatry

authors： Davis BA,Durden DA,O'Reilly RL

更新日期：1991-01-01 00:00:00

abstract：:1. Genetic databases are an expanding and readily accessible repository of information on the mapping and sequencing of the human genome, and that of other model organisms. The integration and application of this information to neuropsychiatric disease is illustrated using neuroendocrine and neuropharmacologic data, c...

journal_title：Progress in neuro-psychopharmacology & biological psychiatry

authors： Jaworski M,Edwards E

更新日期：1991-01-01 00:00:00

abstract：:1. Studies on the metabolism of the tricyclic antidepressant trimipramine (TMP) in the rat are described. 2. Twenty metabolites of TMP were isolated from rat urine after enzymatic hydrolysis and their structures were determined by a gas chromatographic-mass spectrometric (GC-MS) method. 3. Twelve TMP metabolites were ...

journal_title：Progress in neuro-psychopharmacology & biological psychiatry

authors： Hussain MS,Coutts RT,Baker GB,Micetich RG,Daneshtalab M

更新日期：1991-01-01 00:00:00

abstract：:1. The clinical literature regarding the effects of various psychotropic agents on self-injurious behavior is reviewed. Anecdotal reports, open trials and controlled studies are each reviewed. 2. The absence of controlled studies and the failure to distinguish self-injurious behaviors from other forms of aggression ar...

journal_title：Progress in neuro-psychopharmacology & biological psychiatry

authors： Luchins DJ

更新日期：1990-01-01 00:00:00

abstract：:1. Preclinical studies reveal that long-term treatment with antidepressant drugs induces significant changes in serotonergic (5-HT) receptor sensitivity. Similarly, clinical studies suggest that brain 5-HT function is abnormal in depression. Of the available methodologies for conducting such clinical studies, the phar...

journal_title：Progress in neuro-psychopharmacology & biological psychiatry

authors： Price LH,Charney DS,Delgado PL,Goodman WK,Krystal JH,Woods SW,Heninger GR

更新日期：1990-01-01 00:00:00

abstract：:1. Immunohistochemical methods were used to identify dopaminergic, noradrenergic, cholinergic and serotonergic axons in cynomolgus monkey prefrontal cortex. 2. The densities of dopaminergic and noradrenergic systems varied in a similar fashion across prefrontal cortical regions, whereas the densities of cholinergic an...

journal_title：Progress in neuro-psychopharmacology & biological psychiatry

authors： Lewis DA

更新日期：1990-01-01 00:00:00

abstract：:1. Quantitative electroencephalographic activity (EEG), together with bioelectric measures of the peripheral nervous system, provide us with unique non-invasive tools for investigating neurobiological issues relating to panic disorder. 2. During recordings of non-panic states, patients with panic disorder exhibit a de...

journal_title：Progress in neuro-psychopharmacology & biological psychiatry

authors： Knott VJ

更新日期：1990-01-01 00:00:00

abstract：:1. Plasma melatonin concentrations were determined after administration of single oral doses (100, 200 and 300 mg) of moclobemide, a reversible inhibitor of monoamine oxidase (MAO) with predominant effects on the A-type of the enzyme, to eight young, healthy male volunteers in a double-blind, random-order, placebo-con...

journal_title：Progress in neuro-psychopharmacology & biological psychiatry

authors： Scheinin M,Koulu M,Vakkuri O,Vuorinen J,Zimmer RH

更新日期：1990-01-01 00:00:00

abstract：:1. The plasma levels of L-tryptophan (L-TRP) and the sum of five competing amino acids (CAA) namely tyrosine, phenylalanine, valine, leucine, isoleucine, were determined in 79 depressed females categorized according to the DSM-III. 2. In these patients the authors measured several parameters known to affect the availa...

journal_title：Progress in neuro-psychopharmacology & biological psychiatry

authors： Maes M,Vandewoude M,Schotte C,Martin M,D'Hondt P,Scharpe S,Blockx P

更新日期：1990-01-01 00:00:00

abstract：:1. The relationship between 14C-serotonin uptake, 3H-imipramine binding and surface area was studied in blood platelets. 2. Platelet rich plasma from 5 normal subjects was divided into 5 size subfractions by differential centrifugation and the total surface areas computed from platelet size profiles. 3. Linear relatio...

journal_title：Progress in neuro-psychopharmacology & biological psychiatry

authors： Demet EM,Chicz-Demet A,Shaffer E,Ocariz J

更新日期：1990-01-01 00:00:00

abstract：:1. Cysteamine is formed by degradation of coenzyme A (CoA) and causes somatostatin (SS), prolactin and noradrenaline depletion in the brain and peripheral tissues. 2. Cysteamine influences several behavioral processes, like active and passive avoidance behavior, open-field activity, kindled seizures, pain perception a...

journal_title：Progress in neuro-psychopharmacology & biological psychiatry

authors： Vécsei L,Widerlöv E

更新日期：1990-01-01 00:00:00

abstract：:1. We evaluated the behavioral response of guinea pigs to hallucinogenic agents in order to characterize the response of this species to a variety of known hallucinogenic drugs. 2. The systemic injection of LSD in the guinea pig elicited a "myoclonic-like" response the frequency of which was dose-dependent. This behav...

journal_title：Progress in neuro-psychopharmacology & biological psychiatry

authors： Carvey P,Nausieda P,Weertz R,Klawans H

更新日期：1989-01-01 00:00:00

abstract：:1. The erectile response to the short-acting dopamine (DA) receptor agonist, apomorphine (Apo) HCl (0.25, 0.5, 0.75 and 1.0 mg sc), and placebo was evaluated in 28 impotent patients and penile circumference monitored using a mercury strain gauge and strip chart recording. 2. A full erection (increment in penile circum...

journal_title：Progress in neuro-psychopharmacology & biological psychiatry

authors： Lal S,Tesfaye Y,Thavundayil JX,Thompson TR,Kiely ME,Nair NP,Grassino A,Dubrovsky B

更新日期：1989-01-01 00:00:00

abstract：:1. Male Sprague-Dawley rats were injected with saline, L-Dopa or pargyline. 2. Synaptic vesicles were prepared from whole brain homogenates. Catecholamines and their metabolites in brain tissues and in synaptic vesicles were measured by high performance liquid chromatography with electrochemical detection. 3. L-Dopa a...

journal_title：Progress in neuro-psychopharmacology & biological psychiatry

authors： Buu NT,Lussier C

更新日期：1989-01-01 00:00:00

abstract：:1. The great interest for new drugs having cognition enhancing properties is highlighted, particularly for the treatment of dementia of Alzheimer type. 2. A short survey is given of the pharmacological models currently used to mimic cognitive impairment. 3. A systematic survey is given of the major cognition enhancing...

journal_title：Progress in neuro-psychopharmacology & biological psychiatry

authors： Merlini L,Pinza M

更新日期：1989-01-01 00:00:00

abstract：:1. Behavioural experiments were carried out on adult rats made hypothyroid and hyperthyroid. The hypothyroid rats in an "open field" situation reduced the number of squares crossed and boluses defecated, the hyperthyroid rats reduced the number of squares crossed. A swimming endurance was conducted to evaluate the phy...

journal_title：Progress in neuro-psychopharmacology & biological psychiatry

authors： Fundaro A

更新日期：1989-01-01 00:00:00

abstract：:1. Tryptophan increases 5HT synthesis, but the extent to which it increases 5HT release and therefore 5HT function is unclear. 2. The possibility that increased 5HT levels will lead to increased 5HT release is enhanced when 5HT neurons are firing at a higher rate. The rate of firing of 5HT neurons is increased as the ...

journal_title：Progress in neuro-psychopharmacology & biological psychiatry

authors： Young SN,Teff KL

更新日期：1989-01-01 00:00:00

abstract：:1. As impairment of attention has long been recognized as a clinical feature of depression, we undertook to evaluate in depressed subjects and controls a feature of the event-related brain potentials (ERP) the N100 wave which has been linked to attentional processes. 2. This study involved collection of EEG data in an...

journal_title：Progress in neuro-psychopharmacology & biological psychiatry

authors： Coffman JA,Torello MW,Lewis CE,Fortin LD,Martin DJ

更新日期：1989-01-01 00:00:00

abstract：:1. Dopamine agonists and dopamine releasers act at the level of the striatum to activate a mossy fiber pathway which in turn increases cerebellar cGMP in the rodent. 2. CCK acts to both decrease basal cerebellar cGMP levels as well as to antagonize increases in cerebellar cGMP elicited by dopaminergic agonists and rel...

journal_title：Progress in neuro-psychopharmacology & biological psychiatry

authors： Wood PL

更新日期：1989-01-01 00:00:00

abstract：:1. The possible influence of haloperidol and its metabolite plasma levels on clinical outcome in schizophrenic patients was evaluated. 2. 18 schizophrenic inpatients diagnosed according to DSM III, were treated with conventional haloperidol p.o. for four weeks. 3. Plasma levels of haloperidol and its reduced metabolit...

journal_title：Progress in neuro-psychopharmacology & biological psychiatry

authors： Altamura C,Mauri M,Cavallaro R,Colacurcio F,Gorni A,Bareggi S

更新日期：1988-01-01 00:00:00

abstract：:1. Anti-depressant drugs alter the period of circadian rhythms under free running conditions. We have examined whether treatment with anti-depressants alters such rhythms under conditions of entrainment to a lighting cycle or following a phase advance of the lighting. 2. In the first experiment, following entrainment ...

journal_title：Progress in neuro-psychopharmacology & biological psychiatry

authors： Brown GM,Seggie J

更新日期：1988-01-01 00:00:00

abstract：:1. The effects of intravenous infusion of desipramine (1, 3, 10, and 60 mg/kg/day), amitriptyline, zimelidine, iprindole (3, 10, 30, 60, and 100 mg/kg/day each), imipramine (10, 30, and 100 mg/kg/day), or U-48753E (1, 3, 10, and 30 mg/kg/day) on the density of central beta-adrenergic receptors (beta-AR) were investiga...

journal_title：Progress in neuro-psychopharmacology & biological psychiatry

authors： Sethy VH,Day JS,Cooper MM

更新日期：1988-01-01 00:00:00

abstract：:1. CCK-peptides are distributed throughout the whole brain with the exception of the cerebellum. 2. There is strong evidence that they act as neuromodulators on the noradrenergic, opioid and mainly dopaminergic system. 3. CCK reduces food-intake. However, tolerance occurs, when chronically given. Thus, potential benef...

journal_title：Progress in neuro-psychopharmacology & biological psychiatry

authors： Albus M

更新日期：1988-01-01 00:00:00

abstract：:1. A latent inhibition paradigm was used to test the proposition that lithium increases rats' capacity to ignore an irrelevant stimulation. 2. In latent inhibition, non-reinforced presentations of the stimulus in the preexposure phase are said to lead the animal to ignore this stimulus, therefore reducing its later as...

journal_title：Progress in neuro-psychopharmacology & biological psychiatry

authors： Cappeliez P,Moore E

更新日期：1988-01-01 00:00:00

abstract：:1. As part of a systematic investigation of the effects of lithium administration on neuroendocrine function we investigated the luteinizing hormone (LH) response to luteinizing hormone releasing hormone (LHRH) of healthy males. 2. In healthy volunteers after 3 weeks of therapeutic doses of lithium the LH response to ...

journal_title：Progress in neuro-psychopharmacology & biological psychiatry

authors： Grof E,Brown GM,Grof P,Saxena B

更新日期：1988-01-01 00:00:00

abstract：:1. Seven patients with TD were treated with a single dose of ceruletide 0.8 microgram/kg i.m. 2. EMG and MV were recorded, and the average power spectrum was computed. 3. Effect of ceruletide on TD within 2 hr after injection was varied (3 cases: inhibitory, 2 cases: facilitatory, 2 cases: no effect). 4. Two patients ...

journal_title：Progress in neuro-psychopharmacology & biological psychiatry

authors： Nishikawa T,Tanaka M,Tsuda A,Koga I,Uchida Y

更新日期：1988-01-01 00:00:00

abstract：:1. Behavioral and EEG responses were examined in nonalcoholic males with (FH+) and without (FH-) a family history of alcoholism following the consumption of a placebo and real beer. 2. FH+ subjects were less confident of being able to resist another drink following consumption of the placebo and reported higher taste ...

journal_title：Progress in neuro-psychopharmacology & biological psychiatry

authors： Kaplan RF,Hesselbrock VM,O'Connor S,DePalma N

更新日期：1988-01-01 00:00:00

abstract：:1. An assay was developed using sucrose gradient purified platelet plasma membranes which allowed detection, for the first time in patients, of both super-high affinity (KD = 17 pM) and high affinity (KD = 1.7 nM) binding sites. 2. Limited Scatchard plot analyses were performed on platelet membranes from depressed pat...

journal_title：Progress in neuro-psychopharmacology & biological psychiatry

authors： Piletz JE,Halaris A

更新日期：1988-01-01 00:00:00

abstract：:1. Within triads of rats, individuals can be discerned according to their competition for sucrose-pellets as a high-, a medium- and a poor-performing animal. 2. The competition-rates, expressed as scores, are affected by serotonergic drugs: upon inhibiting tryptophan-hydroxylase, the characteristic abstention of the p...

journal_title：Progress in neuro-psychopharmacology & biological psychiatry

authors： Gentsch C,Lichtsteiner M,Feer H

更新日期：1988-01-01 00:00:00

abstract：:We explored whether the elevation of RBC-choline and choline ratio (RBC-choline/plasma-choline) by lithium is a specific effect of lithium, whether these choline parameters are characteristics of the individual patient, and whether they are related to prophylactic lithium response. In lithium-treated patients RBC-chol...

journal_title：Progress in neuro-psychopharmacology & biological psychiatry

authors： Haag M,Granzow L,Greil W,Haag H

更新日期：1987-01-01 00:00:00

abstract：:The present study investigated the effect of monoamine oxidase inhibitors, nialamide which is a non specific monoamine oxidase inhibitor (MAOI), toloxatone which is a A type MAOI and L-deprenyl which is a B type MAOI compared with classical tricyclic antidepressants (clomipramine, desipramine and imipramine), on the e...

journal_title：Progress in neuro-psychopharmacology & biological psychiatry

authors： Martin P,Soubrie P,Simon P

更新日期：1987-01-01 00:00:00

abstract：:1. Kety hypothesized that forebrain norepinephrine acted to selectively enhance cell firing in neurons receiving environmental inputs during affectively important events. He further suggested that norepinephrine could act to induce a 'persistent facilitation' of the inputs which accompany affectively important events ...

journal_title：Progress in neuro-psychopharmacology & biological psychiatry

authors： Harley CW

更新日期：1987-01-01 00:00:00

abstract：:There is some evidence in animals that dopamine (DA) affects melatonin secretion. The effect of apomorphine (Apo), a selective DA receptor agonist, and placebo on day-time melatonin secretion was studied in six normal men. Apo HCl in a dose (0.5 mg sc) which increased growth hormone secretion in all subjects had no ef...

journal_title：Progress in neuro-psychopharmacology & biological psychiatry

authors： Lal S,Isaac I,Pilapil C,Nair NP,Hariharasubramanian N,Guyda H,Quirion R

更新日期：1987-01-01 00:00:00

abstract：:During nonpathological aging, quantitative changes occur in the pre- and post-synaptic elements of both the dopamine and serotonin systems. The level of dopamine in the human striatum declines up to 50% with age, while smaller and more variable changes are found in rodent brain (0-30%). Postsynaptically, the density o...

journal_title：Progress in neuro-psychopharmacology & biological psychiatry

authors： Morgan DG

更新日期：1987-01-01 00:00:00

abstract：:Alterations in several neurotransmitter systems in brain have been implicated in the pathophysiology of hepatic coma (HC). Studies on human autopsy material are few. We investigated 3H-quinuclidinylbenzilate (QNB), 3H-spiperone, 3H-imipramine, 3H-PN-200-110, 3naloxone, 3H-flunitrazepam, 3H-muscimol, 35S-t-butylbicyclo...

journal_title：Progress in neuro-psychopharmacology & biological psychiatry

authors： Lal S,Quirion R,Lafaille F,Nair NP,Loo P,Braunwalder A,Wood P,Williams M

更新日期：1987-01-01 00:00:00

abstract：:Chronic ingestion of ethyl alcohol in pre-weanling rats can decrease whole-brain levels of sialic acid (SA), an acidic sugar that serves as terminal groups on glycolipids (gangliosides) and glycoproteins. Because SA occurs in both classes of membrane-bound chemicals, the alcohol effect could be on either or both paren...

journal_title：Progress in neuro-psychopharmacology & biological psychiatry

authors： Klemm WR,Foster DM

更新日期：1986-01-01 00:00:00

abstract：:A system is described for avoidance conditioning of the budgerigar (Melopsittacus undulatus), for sound patterns consisting of one or two sequential subunits and to discriminate between two closely resembling sounds. Electric shock was used as the unconditioned stimulus. Simple conditioning was accomplished in about 3...

journal_title：Progress in neuro-psychopharmacology & biological psychiatry

authors： Ven Murthy MR,Lambert R

更新日期：1986-01-01 00:00:00

abstract：:The cholinergic hypothesis of memory dysfunction has guided most of the recent proposals for treating the primary symptoms of AD. The efficacy of these treatments has been severely limited. This review examines two major lines of evidence which suggest that the cholinergic hypothesis may have to be expanded and revise...

journal_title：Progress in neuro-psychopharmacology & biological psychiatry

authors： Pomara N,Bagne CA,Stanley M,Yarbrough GG

更新日期：1986-01-01 00:00:00